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Posts Tagged ‘Biochemistry’

Our goal is to understand the biochemical basis of CELL PLASTICITY. We use state-of-the-art mouse and cell models to study the cGMP signalling pathway in the mammalian cardiovascular and nervous system (for overview, see Kemp-Harper B & Feil R. Sci Signal. 2008, 1:pe12). The projects involve analyses at the whole organism, cellular and molecular level. Accordingly, a broad spectrum of methods is combined, from transgenic mice (e.g. Cre/lox-based conditional mouse mutants; see Feil S, Valtchev…

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Our goal is to understand the biochemical basis of CELL PLASTICITY, with a focus on the role of cGMP signalling in the mammalian cardiovascular and nervous system (for overview, see Kemp-Harper B & Feil R. Sci Signal. 2008, 1:pe12). The projects combine analyses at various levels, from ‘in vivo’ to ‘in cellula’ to ‘in vitro’. We seek a post-doc / group leader with background in animal work and transgenic mouse technology (see Feil S, Valtcheva N, Feil R. Methods Mol Biol. 2009, 530:343-363) a…

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You will be using advanced statistical and bioinformatics techniques to investigate the genetic architecture of cardiovascular disease (e.g. stroke, coronary heart disease and peripheral artery disease) using data from the SMART study (Second Manifestations of Arterial Disease). The goal is to gain…

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The Department of Biochemistry at the University of Wisconsin-Madison (www.biochem.wisc.edu) invites applications for a position in biochemistry at the Assistant Professor level. The Department is interested in candidates working at the cutting edge in all areas of biochemistry (e.g., chemical, structural, cellular, developmental and physiological). The University and Department provide an excellent environment for the development of an outstanding research program. The successful candidat…

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Description: The Department of Biochemistry at the University of Washington School of Medicine invites applications for two tenure-track positions at the Assistant Professor level. We seek creative scientists who conduct research on important biological problems using the tools of biochemistry, structural biology or biophysics, cell or molecular or developmental biology, or related fields. Our department is also strongly committed to teaching and service at the undergraduate, graduate, and …

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Analytical Biochemistry Team Leader – Proteins/ Peptides c30-35k
South AF/015525

An Analytical Team Leader for a Bioanalytical Development in the field of peptides and proteins and peptides is urgently required for a pharmaceutical organisation.

Key Responsibilities
• Manage, co-ordinate and implement the development of analytical methodologies
• Develop and validate analytical methods for the analysis of biopharmaceuticals and peptides
• Assume responsibility for the analytical activities of assigned projects within PDS
• Set and maintain appropriate goals and standards of performance for the team
• To utilise the resources available to ensure that they contribute maximum effectiveness in achieving project objectives.
• To generate, assimilate and evaluate technical and scientific data and issue reports in line with project objectives.

Qualifications and Experience
• Extensive experience of relevant industrial experience covering the areas given below:
• Biochemistry background
• Experience in protein and peptide analytical techniques
• Sound knowledge of protein chemistry and the techniques required for protein characterisation
• Experience in the development and validation of analytical methods for the analysis of biopharmaceuticals and peptides
• Experience or a good understanding of biological (cell based) assays validated for GMP release and stability testing of biopharmaceuticals
• To have knowledge and experience of biological techniques such as
SDS-PAGE, Iso-electric focusing, ELISA, General Column Chromatography Capillary Electrophoresis, Functional assays
• Pharmacopoeia requirements for sterile products
• Working knowledge of cGMP

To Apply
If you would like to be considered for this role, please contact Alison Fisher AF/015525, outlining your particular skills and experience and their relevance to this post. Please call on 020 7421 5200, or reply via email, entering the job title and reference code in the subject field to alison.fisher@hs-scientific.co.uk

For up to date career opportunities please visit www.hs-scientific.co.uk
Due to a high volume of applicants only shortlisted candidates will be contacted. If you are not contacted within seven days of submitting your CV please assume that your application will not be taken further. If you wish to receive feedback to obtain why your application was unsuccessful please use the contact details provided on the advert.

New Scientist Jobs

The PhD project is part of extensive research on the role of glycosphingolipids in pathological processes in man and the therapeutic value of pharmacological manipulations in this respect. The PhD is closely linked to a senior post doc.
Obesity is increasing at an alarming rate and connected to this, pathological states such as insulin resistance, type 2 diabetes and atherosclerosis. An important contributing factor to insulin resistance/type 2 diabetes is a chronic low grade of inflammation. Recently we have found that inhibition of glycosphingolipid synthesis by using iminosugars improves whole body insulin sensitivity in rodent models of obesity/type 2 diabetes, reduces hepatic steatosis and lowers inflammation both in adipose tissue and liver. The exact mechanism for this observed insulin sensitizing actions is not unravelled yet and is subject of current research.
The Department of Medical Biochemistry encompasses various researchers studying the role of glycosphingolipids in health and disease. Close collaborations exist with clinicians, in particular endocrinologists and organic chemists. Cell biological approaches, animal models and clinical related studies are conducted in order to address the mechanisms by which glycosphingolipids contribute to type 2 diabetes. Research will be carried out in a competitive, international and stimulating environment.

For most recent publications see http://bibliotheek.amc.uva.nl/cgi-bin/cgiwrap/mb/wetreg/WetRegApp.cgi?Mode=LZ_zoek&zoekveld1=afdelingid&zoekterm1=Medische Biochemie&zoekid1=3&jaar=2010

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TENURE-TRACK FACULTY POSITION

Departments of Chemistry and Biochemistry and Biology

USTAR Initiative

Utah State University

The Utah Science, Technology and Research (USTAR) initiative, along with the Departments of Chemistry and Biochemistry and Biology at Utah State University, invites applications for a tenure-track position at any rank. Candidates must have a Ph.D. in biochemistry, biology, or a related field, with postdoctoral and faculty experience preferred. The successful applicant will develop a funded research program in some area of phototrophic microbes, and will be expected to teach at the graduate and undergraduate levels. Preference will be given to candidates with research programs that complement the USTAR Biofuels research program goals of developing phototrophic microbes as a feedstock for biofuels. The position is funded by a grant from the USTAR initiative, a statewide program that aims to promote commercialization of technologies at the state universities.

Applicants should submit curriculum vitae, a concise description of future research projects, associated major research infrastructure needs, and the names and e-mail addresses of three references online at website: http://jobs.usu.edu requisition 052021). Evaluation of applications will begin March 15, 2010, and will continue until the position is filled.

For further information please visit our website: http://www.chem.usu.edu.

Utah State University is an Equal Opportunity/Affirmative Action Employer committed to assembling a diverse faculty. Women and members of minority groups are strongly encouraged to apply.

New Scientist Jobs

Understanding the molecular and cellular basis of Angelman Syndrome

Angelman syndrome is a severe neurological disorder, affecting 1:12,000 children, that is caused by the loss of a functional copy of the maternal UBE3A gene. Although the UBE3A gene was identified 16 years ago to encode the ubiquitin protein ligase E6AP, little progress has been made that provides insight in its role in neuronal function.
This ZonMw funded project involves a strong multi-disciplinary effort from a neurobiology laboratory (Erasmus Medical Center) specialized in synaptic plasticity using mouse models, and from a biochemical laboratory (Academic Medical Center) specialized in protein-protein interaction and ubiquitination to get more insight in the most pressing questions concerning the mechanisms underlying Angelman syndrome.

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